Some plugins are causing grief for those upgrading to 2.8.
- HyperDB needs to be updated to the latest version, otherwise tags won’t save.
- DB Cache also prevents tags from being saved. I haven’t seen an update for it yet.
- Plugins that load old versions of jQuery for all admin pages will break all kinds of stuff. Plugins should use the version of jQuery that ships with WP. If a plugin must use a particular version of jQuery, that version should be queued only for the plugin’s own pages.
- Themes that call get_categories() from functions.php before the init action fires will fail. 2.8.1 will workaround this, but ideally these themes should update so that they can handle custom taxonomies properly.